Alzheimer's and Advanced Parental Age in a Study in Japan in 1989

1: Arch Neurol. 1989 Jan;46(1):38-9. Links
A community-based study of parental age at the birth of patients with dementia of the Alzheimer type.Urakami K, Adachi Y, Takahashi K.
Division of Neurology, Tottori University School of Medicine, Yonago, Japan.

The association of dementia of the Alzheimer type (DAT) with parental age at the birth of patients who develop DAT was investigated in a community-based study in Japan. Both maternal and paternal ages of patients who have developed DAT are significantly higher than those in controls and multi-infarct dementia. This study suggests that advanced age may become a cause of chromosome abnormality, and advanced parental age at subjects' birth may be a possible risk factor in DAT.