Prevention of Neurodevelopmental Disorders - Lower Paternal Age SPERM NOT EGGS MUTATE SPERM STEM CELLS DIVIDE EVERY 16 DAYS

Guys have all your children before your 35th birthday to prevent autism, schizophrenia, diabetes, MS, cancers, autoimmune disorders, etc. Best to father babies before 33. The health of the placenta is affected by the sperm DNA. This is not what you've been taught, I know.


Neurodevelopmental Disorders
in proportion to the demographics of
paternal childbearing age. Furthermore, this risk has implications for public health and for the primary prevention of these disorders.


Mutations May Occur in Any One of a Number of
Genes Involved in Neurodevelopment. Thousands of
genes are estimated to play a role in neurodevelopment;
therefore, it is possible that mutations in many genes could cause autism etc.



New Mutations and Human Genetic
Disease
Association With Paternal Age. The major source of
new mutations in human populations is from advancing
paternal age (see Crow 1999). Weinberg (1912) had suggested
that aging parental germ cells may be prone to
mutation after observing that achondroplasia was more
common in last-born siblings. In 1955, Penrose demonstrated
that later paternal age, but not maternal age, was
predictive of de novo mutations. He proposed that mutations
arose by DNA copy errors that accumulate over the
many replication cycles that occur in the male germ line.
Spermatogonial cells replicate every 16 days, approximating
200 divisions by age 20, and 660 by age 40 (see
Drake et al. 1998). By contrast, oocytes undergo only 24
cell divisions, of which all but the last occur before a
woman's birth. In addition, as men age, mutations may
increase because spermatogenesis occurs in the presence
of declining testosterone, lower levels of DNA proofreading
and repair enzymes (Tarin et al. 1998), and reduced
antioxidant enzyme activity, along with the limitations in
vascular supply and reduced cellular efficiency that
accompany aging in other tissues. New genetic diseases
arising from mutations are likely to minimally affect 1 of
every 200 offspring of men older than 40 years (Friedman
1981).
Although