Does The Male Aging Influence Clinical Outcomes On ICSI Cycles?

Does The Male Aging Influence Clinical Outcomes On ICSI Cycles?
Main Category: Urology / Nephrology
Also Included In: Men's health
Article Date: 02 Jul 2008 - 0:00 PDT



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ORLANDO, FL (UroToday.com) - It has been established that aging has an adverse affect on a woman's reproductive potential by natural or assisted reproductive techniques (ART).

These authors attempted to assess the effect of increasing paternal age on ART success. This retrospective analysis included 760 ICSI cycles with fresh spermatozoa. The cycles were divided depending on sperm concentration: < 20x106sperm/ml (n=220) and ≥ 20x106sperm/ml (n=540). Multiple linear regression analysis was performed. When sperm concentration were < 20x106sperm/ml there was a negative correlation between male age and implantation rate. Multivariate regression adjusted to maternal age showed the influence of exclusively male aging on implantation (p=0.014). When the sperm concentration were ≥ 20x106sperm/ml, there was no correlation between male age and implantation rate (r= -0.052; p=0.1838), however maternal age negatively influenced implantation rates (p < 0.0001).

Editorial Comment: Recently there has been significant attention paid to the effect of male aging on reproductive outcomes (eg. Genetic disorders, Alpert syndrome, autism, Down syndrome and schizophrenia (see Lazarou and Moranthaler in Urologic Clinics of North America: Male Infertility: Current Concepts and Controversies. Ed Harris M .Nagler). This study also suggests the possible impact of increasing paternal age on reproductive success as defined as implantation. The authors did not study the full term delivery rates of this same population.

Presented by Renata C Ferreira, MD, Tatiana C S Bonetti, MD, Daniela Braga, MD, Priscila Queiroz, MD, Fabio F Pasqualotto, MD, Assumpto Iaconelli, MD, and Edson Borges, MD, at the Annual Meeting of the American Urological Association (AUA) - May 17 - 22, 2008. Orange County Convention Center - Orlando, Florida, USA