Sunday, August 23, 2009

What will reduce the amount of autism and schizophrenia in the population?

What will reduce the amount of autism and schizophrenia in the population?
August 22, 2009 | By admin In Autism |
Alex

90 % of autism and and 85 -90 % of schizophrenia is de novo, sporadic, non-familial
Is paternal age and risk of autism plausable biologically?

RESULTS: There was a significant monotonic association between advancing paternal age and risk of ASD. Offspring of men 40 years or older were 5.75 times (95% confidence interval, 2.65-12.46; P<.001) more likely to have ASD compared with offspring of men younger than 30 years, after controlling for year of birth, socioeconomic status, and maternal age. Advancing maternal age showed no association with ASD after adjusting for paternal age. Sensitivity analyses indicated that these findings were not the result of bias due to missing data on maternal age. CONCLUSIONS: Advanced paternal age was associated with increased risk of ASD. Possible biological mechanisms include de novo mutations associated with advancing age or alterations in genetic imprinting.

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