Wednesday, October 24, 2007

35 Years: the Border Between Good and Bad Sperm?

Sperm Abnormalities Correlate With Age: Presented at ASRM
By Crina Frincu-Mallos, PhDWASHINGTON, DC -- October 23, 2007:
At the ends of the spectrum, in the subgroup of patients younger than 30 years, the mean rate of DNA fragmentated spermatozoa was 14.05%, while in the subgroup above 40 years old, the percentage went up to 20.27%, said the researchers.

This is not new news. It is just that this information does not get communicated to the public:

Tuesday, 15 October, 2002, 07:44 GMT 08:44 UK
Male biological clock is ticking

Sperm cells accumulate damage over time
The chances of a man having children dip past his 35th birthday, researchers have found.
The researchers, from the University of Washington in Seattle, found that damage to the genetic material containing sperm cells increases with age.
We found there is a significant change by the age of 35
Dr Narendra SinghUnlike most other cells in the body, sperm cells are unable to repair this damage.
In addition, the researchers found that as a man gets older he loses his natural ability to weed out unhealthy sperm cells through a process known as apoptosis.
This means that there is a greater chance that a damaged sperm cell will successfully fertilise the female egg.
This could mean that the risk of miscarriage is increased or, at the other end of the scale, that children have a greater chance of developing mild abnormalities such as uneven teeth, or asymmetrical limbs.
Lead researcher Dr Narendra Singh told the BBC: "We found there is a significant change by the age of 35."
Sperm quality
Dr Singh's team examined sperm quality in 60 men aged between 22 and 60. All had healthy sperm counts.
The researchers found that men aged 35 and older had higher concentrations of sperm with broken strands of DNA, and that the damage was greater.

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Tuesday, October 09, 2007

An Excellent Article on the male biological clock by Mark Teich in PYSCHOLOGY TODAY

He nails it. Every high school and college should use this to teach about autism and other de novo /sporadic genetic disease

A must read------- the whole article!

A Man's Shelf Life

By:Mark Teich
Page 2 of 4
Male versus Female Mutations
"Scientists have long known that advanced paternal age (like increased maternal age) played some role in fertility problems and birth defects. Yet because the reports mainly involved children who died before birth or who had extremely rare disorders, no one really rang the alarm. Now, with new studies linking the father's age to relatively frequent, serious conditions like autism, schizophrenia, and Down syndrome, the landscape is shifting.
Women have unfairly borne the brunt of the blame for birth defects. When the conditions were familial, passed on through chromosomal lineage, women were somehow widely believed culpable, even though such defects can be traced to either partner. "But what we're finding now is that in humans as well as in other mammals, when there's a new genetic change—called 'de novo or sporadic point mutation'—it almost always happens in the male parent," says Dolores Malaspina, chair of psychiatry at New York University Medical Center. And these de novo mutations increase in frequency with the age of the male parent."


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