Friday, July 13, 2007

Nobody Tells People That The Biologically Best Time To Have Children is in One's Twenties to 32

The Infertility Business Ignores Genetic Realities for Profit.

1: Med J Malaysia. 2006 Dec;61(5):599-607.Predictors of intrauterine insemination success.Zainul MR, Ong FB, Omar MH, Ng SP, Nurshaireen A, Rahimah MD, Mariam S, Zolaidah M, Sharifah-Teh NS, Saniros A, Hasnita B.
Department of O&G, Medical Faculty, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak 56000, Cheras, Kuala Lumpur.

Intrauterine insemination (IUI) remains a therapeutic option within means of the majority of infertile couples in Malaysia. Therefore additional information on predictors of IUI success in the local context would provide a more concrete basis for counseling patients on expectations and treatment options. A retrospective analysis of 297 couples who underwent 445 IUI cycles from Jan 2005-Mar 2006 was undertaken. Four fifths were Malay with a mean paternal and maternal age of 35.53 +/- 5.82 (range 24-59) and 33.02 +/- 4.69 (range 21-46) years respectively. Causes of infertility were idiopathic (50%), endometriosis (17%) and anovulation/polycystic ovarian syndrome (15%). Almost 10% were oligoastenoteratozoospermic with another 23% oligozoospermic or astenozoospermic. Combined male and female factors occurred in 26%. A pregnancy rate (PR) of 9.4% per cycle; 14.1% per couple with a cumulative PR of 36.7% per 4 cycles was achieved. Those who became pregnant were significantly younger (31.29 +/- 4.43 vs. 33.21 +/- 4.68 years, p = 0.011) and had more follicles (13.95 +/- 9.72 vs. 11.43 +/- 6.67, p = 0.029) at the time of insemination. PR depreciated with maternal age and semen quality. Maternal and paternal age was inversely correlated to the number of follicles recruited (r = -0.30, p < 0.0005) and progressive sperm motility (r = -0.125, p = 0.013) respectively.

PMID: 17623962 [PubMed - in process]

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Monday, July 09, 2007

Dolores Malaspina, M.D., one of the most articulate and knowledgeable psychiatrists in the world and yet the public is not warned about advancing paternal age as Dr. Philip Gorwood of France would advocate. Is he the much more compassionate of doctors?

Paternal Age and Schizophrenia An Expert Interview with Dolores Malaspina, M.D., M.P.H.
(Great Neck, NY -

March 23, 2006) — Scientists have linked paternal age to genetic diseases since the 1950s, and some have suggested an association between the age of the father and the risk for schizophrenia. In 2001, Dolores Malaspina, M.D., M.P.H., and her colleagues reported their research identifying a relationship between paternal age and the occurrence of schizophrenia. On behalf of Medscape* Jessica Gould interviewed Dr. Malaspina, Professor of Clinical Psychiatry at Columbia University and Research Psychiatrist at New York State Psychiatric Institute in New York City. Dr. Malaspina elaborates on her research and speaks about new directions in genetic research on schizophrenia. (NARSAD NOTE: Dr. Malaspina was a NARSAD 1993 and 1995 Young Investigator and a 2001 Independent Investigator.)Medscape: Tell me about your research on paternal age and schizophrenia.Dolores Malaspina: I have been compelled by the idea that schizophrenia is not a single disease. The consensus in the field is that schizophrenia is a syndrome, and a syndrome is a collection of different disorders. Yet there is still some controversy over whether or not there are variants of schizophrenia that might have separate causes and respond differently to various medications.Since beginning my research in the late 1980s, I have focused on this heterogeneity, and one way that I've done that is by examining aspects of the disease in people who come from densely affected families, where two or more relatives have schizophrenia, and comparing them with cases of schizophrenia that have no family history of any chronic psychosis.Now, in genetic research, it's known that for human genetic diseases, when a new case presents itself in a family, the mutation almost always arises during spermatogenesis. We have known for almost 100 years that the late born children in a family have more new genetic diseases. In the 1950s, a scientist named Penrose showed that only the age of the father predicts these genetic diseases. Over the last decade, it was shown that the risk for many complex genetic diseases was also correlated with paternal age. I thought that if schizophrenia cases with no family history were due to new genetic events, maybe they would also be correlated with the father's age.


1: Eur Psychiatry. 2007 Jan;22(1):22-6. Epub 2006 Dec 4.
Paternal ages below or above 35 years old are associated with a different risk of schizophrenia in the offspring.
Wohl M, Gorwood P.
INSERM U675, 16 rue Henri Huchard 75018 Paris, France.
BACKGROUND: A link between older age of fatherhood and an increased risk of schizophrenia was detected in 1958. Since then, 10 studies attempted to replicate this result with different methods, on samples with different origins, using different age classes. Defining a cut-off at which the risk is significantly increased in the offspring could have an important impact on public health. METHODS: A meta-analysis (Meta Win) was performed, assessing the mean effect size for each age class, taking into account the difference in age class references, and the study design. RESULTS: An increased risk is detected when paternal age is below 20 (compared to 20-24), over 35 (compared to below 35), 39 (compared to less than 30), and 54 years old (compared to less than 25). Interestingly, 35 years appears nevertheless to be the lowest cut-off where the OR is always above 1, whatever the age class reference, and the smallest value where offspring of fathers below or above this age have a significantly different risk of schizophrenia. CONCLUSION: No threshold can be precisely defined, but convergent elements indicate ages below or above 35 years. Using homogeneous age ranges in future studies could help to clarify a precise threshold.
PMID: 17142012 [PubMed - indexed for MEDLINE]1: Eur Psychiatry. 2007 Jan;22(1):22-6. Epub 2006 Dec 4.


Friday, July 06, 2007

It is Time To Be Warned About the Male Biological Clock and To Take It Seriously

Beverly Sills, she married Peter Greenough when he was at least 39 and had three normal children from a prior marriage. Their two children are extremely affected by his older paternal age it seems.
She met Greenough in Cleveland while on a 1955 tour with City Opera. "He winked, which I thought was pretty corny," Ms. Sills told The Christian Science Monitor in 1985, "but it worked." Greenough died last year.

Ms. Sills had three stepchildren from Greenough's previous marriage and two children with her husband: a son, Peter Jr., who is autistic and mentally retarded, and a daughter, Meredith, who suffers from multiple sclerosis and who is deaf.

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Monday, July 02, 2007

Growing the Number of Mental Ill and Cognitively Impaired, Everyone Knows About the iPhone

The purposeful campaign to insure lack of public awareness of the connection between later paternal age and cognitive mental illness despite 50 years of evidence is growing the number of mentally ill, anxious, chronically ill obese, diabetic in the population.

The evidence is in, the studies are loud and clear. Advancing paternal age in the current generation or in prior generations is the cause of the increase in diabetes, in Alzheimer's, in autism, in schizophrenia, in anxiety disorders, in so called autoimmune disorders cancers etc.
Read the blogs for the evidence.

"It is curious that although sperm have been around since the beginning of time, we know so little about what is in them, and what makes them tick, er, swim. So scientists spend a lot of their waking hours trying to compare the structure and content of the proteins of sperm in various species, in order to understand their evolution and origin. For instance, the mutated DNA in the genes of the sperm of older fathers is believed to cause many genetic diseases. It is almost as if a man’s biological clock accelerates mutation in sperm cells in his early ’30s."

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