Growing the Number of Mental Ill and Cognitively Impaired, Everyone Knows About the iPhone

The purposeful campaign to insure lack of public awareness of the connection between later paternal age and cognitive mental illness despite 50 years of evidence is growing the number of mentally ill, anxious, chronically ill obese, diabetic in the population.

The evidence is in, the studies are loud and clear. Advancing paternal age in the current generation or in prior generations is the cause of the increase in diabetes, in Alzheimer's, in autism, in schizophrenia, in anxiety disorders, in so called autoimmune disorders cancers etc.
Read the blogs for the evidence.


"It is curious that although sperm have been around since the beginning of time, we know so little about what is in them, and what makes them tick, er, swim. So scientists spend a lot of their waking hours trying to compare the structure and content of the proteins of sperm in various species, in order to understand their evolution and origin. For instance, the mutated DNA in the genes of the sperm of older fathers is believed to cause many genetic diseases. It is almost as if a man’s biological clock accelerates mutation in sperm cells in his early ’30s."

TYPE 1 DIABETES INCIDENCE INCREASES WITH INCREASING PATERNAL AGE AND OTHER FACTORS WHY NOT INFORM THE PUBLIC?

Richard Insel



Robert Wood Johnson IV
Jackson Laboratory researcher receives JDRF's Grodsky award
Dr. David Serreze honored for work in immunology of type 1 diabetes
New York, NY— May 18, 2007 -- The Juvenile Diabetes Research Foundation, the world’s largest charitable funder of type 1 diabetes research, announced today that Dr. David Serreze, senior staff scientist at The Jackson Laboratory in Bar Harbor, Maine, is the recipient of the 2007 Gerold & Kayla Grodsky Basic Research Scientist Award. The award, among JDRF’s most prestigious, will be given to Dr. Serreze at an awards ceremony tonight at the Marriott Financial Center in downtown Manhattan.

"JDRF is in the business of finding a cure for type 1 diabetes. As such, we work with world-class researchers who share our mission and are making significant progress towards that goal," said Dr. Richard Insel, Executive Vice President of Research at JDRF. "After careful consideration of many excellent candidates, we are thrilled to acknowledge Dr. Serreze for his outstanding work in accelerating the pace of diabetes research."

The Gerold & Kayla Grodsky Award is presented annually to a basic research scientist who has made outstanding contributions to diabetes research. JDRF established the award in 1993 to honor the contributions of Dr. Grodsky’s diabetes research at UCSF over four decades. A gift to JDRF from the Grodskys has made it possible for a monetary award to be presented each year to a Ph.D. researcher who has made an outstanding contribution to the study of diabetes.

Through this year’s award, JDRF recognizes Dr. Serreze’s leadership and innovation in the emerging field of diabetic immunology. The award also reflects his expert advice and service on the JDRF Medical Science Review Committee.

"I’m honored and humbled to receive the Grodsky award from the JDRF," said Dr. Serreze. "Type 1 diabetes is a terrible disease, but with the support of the JDRF family, I hope that work from my laboratory may play some small part in leading to cures for type 1 diabetes."

Dr. Serreze has been with the Jackson Laboratory since 1991. He is also adjunct research professor of medicine at the University of Massachusetts Medical Center, Worcester. A two-time recipient of JDRF’s Mary Jane Kugal Research Award, Dr. Serreze is the author or coauthor of more than 100 research papers. He earned his undergraduate and graduate degrees at the University of Maine.

Type 1 Diabetes is also a Risk Factor For Autism and Advancing Paternal Age is a Risk Factor For Type 1 and Maybe Type 2 Diabetes

WHICH COMES FIRST THE CHICKEN OR THE EGG DID THEY CHECK THE BLOOD OR OTHER SOMATIC CELLS OF THE DIABETIC MEN FOR COPY NUMBER VARIATIONS

Contact: Emma Mason
wordmason@mac.com
44-077-112-96986
European Society for Human Reproduction and Embryology
First research to show that diabetes damages DNA in men's sperm and may affect fertility
Scientists have found that sperm from diabetic men have greater levels of DNA damage than sperm from men who do not have the disease. They warn that such DNA damage might affect a man’s fertility.

In the first study [1] to compare the quality of DNA in sperm from diabetic and non-diabetic men, the researchers from Belfast, Northern Ireland showed that the DNA in the nuclei of the sperm cells had greater levels of fragmentation in diabetic men (52%, versus 32% in non-diabetic men), and that there were more deletions of DNA in the tiny, energy-generating structures in the cells called mitochondria (4 versus 3).

Dr Ishola Agbaje, who undertook the research published online today (Thursday 3 May) in the journal Human Reproduction, said: "As far as we know, this is the first report of the quality of DNA in the nucleus and mitochondria of sperm in diabetes. Our study identifies important evidence of increased DNA fragmentation of nuclear DNA and mitochondrial DNA deletions in sperm from diabetic men. These findings cause concern, as they may have implications for fertility."

The incidence of type 1 and type 2 diabetes is increasing rapidly worldwide. While diet and obesity are known to be key factors in the increase of type 2 (or late onset) diabetes, type 1 diabetes which is usually diagnosed in childhood or adolescence, is increasing by three per cent a year in European children, although the reason for this is not entirely clear. Genetic factors that make people more susceptible, or environmental factors such as viruses that may trigger the onset of type 1 diabetes, could play a role.

Dr Agbaje, a research fellow in the Reproductive Medicine Research Group at Queen’s University, Belfast, said: "If the increasing trend in the incidence of type I diabetes continues, this will result in a 50% increase over the next ten years. As a consequence, diabetes will affect many more men prior to and during their reproductive years. Infertility is already a major health problem in both the developed and developing world, with up to one in six couples requiring specialist investigation or treatment in order to conceive. Moreover, the last 50 years have seen an apparent decline in semen quality. Sperm disorders are thought to cause or contribute to infertility in 40-50% of infertile couples. The increasing incidence of systemic diseases such as diabetes may further exacerbate this decline in male fertility. However, it is not clear to what extent clinics consider information about the diabetic status of their patients when investigating fertility problems." [2]

Dr Agbaje and his colleagues examined sperm from 27 diabetic men, with an average age of 34, and 29 non-diabetic men with an average age of 33. They found that although semen volume was significantly less in diabetic men (2.6 versus 3.3 ml), there were no significant differences in sperm concentration, total sperm output, form and structure of the sperm or their ability to move. When they measured DNA damage they found that the percentage of fragmented nuclear DNA was significantly higher in sperm from the diabetic men and that the number of deletions in mitochondrial DNA was also higher – the number of deletions ranged from three to six (average four) in the diabetic men and from one to four (average three) in the non-diabetic men.

Professor Sheena Lewis, scientific director of the Reproductive Medicine Research Group, said: "Our study shows increased levels of sperm DNA damage in diabetic men. From a clinical perspective this is important, particularly given the overwhelming evidence that sperm DNA damage impairs male fertility and reproductive health. Other studies have already shown that, while the female egg has a limited ability to repair damaged sperm DNA, fragmentation beyond this threshold may result in increased rates of embryonic failure and pregnancy loss. In the context of spontaneous conception, sperm DNA quality has been found to be poorer in couples with a history of miscarriages."

However, Prof Lewis said that it was not possible to say from this current study whether the DNA damage caused by diabetes would have the same effect on men’s fertility and the health of future children as DNA damage caused by other factors such as smoking.

"This is just one, relatively small study that highlights a possible concern. Further studies need to be carried out in order to understand the precise nature of the diabetes-related damage, the causal mechanisms and the clinical significance. Given the global rise in the prevalence of diabetes, it is also vital to examine the reproductive outcomes of pregnancies fathered by diabetic men, and the prevalence of diabetes amongst men attending for infertility treatment," she concluded.

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[1] Insulin dependent diabetes mellitus: implications for male reproductive function. Human Reproduction. doi:10.1093/humrep/dem077.

[2] Studies have estimated the prevalence of diabetes in sub-fertile men as 1% – three times more than expected (0.3%), given the prevalence of diabetes and male infertility in the general population. This suggests that diabetes is having a significant impact on male fertility.